Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-Glucuronosyltransferases

We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the 19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. The glucuronidation of 4-hydroxyindole, a related indole that lacks the N,N-dimethylaminoethyl side chain, was studied as...

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Main Authors: Manevski, Nenad, Kurkela, Mika, Höglund, Camilla, Mauriala, Timo, Court, Michael H., Yli-Kauhaluoma, Jari, Finel, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2835393/
https://ncbi.nlm.nih.gov/pubmed/20007669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.031138
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