Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids

Tetrahydrocannabinol (Δ(9)-THC), the primary psychoactive ingredient in marijuana, is subject to cytochrome P450 oxidation and subsequent UDP-glucuronosyltransferase (UGT)-dependent glucuronidation. Many studies have shown that CYP2C9 and CYP3A4 are the primary enzymes responsible for these cytochro...

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Main Authors: Mazur, Anna, Lichti, Cheryl F., Prather, Paul L., Zielinska, Agnieszka K., Bratton, Stacie M., Gallus-Zawada, Anna, Finel, Moshe, Miller, Grover P., Radomińska-Pandya, Anna, Moran, Jeffery H.
Format: Artigo
Language:Inglês
Published: American Society for Pharmacology and Experimental Therapeutics 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698943/
https://ncbi.nlm.nih.gov/pubmed/19339377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.026898
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