PHENYLALANINE(90) AND PHENYLALANINE(93) ARE CRUCIAL AMINO ACIDS WITHIN THE ESTROGEN BINDING SITE OF THE HUMAN UDP-GLUCURONOSYLTRANSFERASE 1A10

Human UDP-glucuronosyltransferase 1A10 has been identified as the major isoform involved in the biotransformation of a wide range of phenolic substrates, including native estrogens and their oxidized metabolites. Our recent studies point to the F(90)-M(91)-V(92)-F(93) amino acid motif of UGT1A10, wh...

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Autori principali: Starlard-Davenport, Athena, Xiong, Yan, Bratton, Stacie, Gallus-Zawada, Anna, Finel, Moshe, Radominska-Pandya, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829494/
https://ncbi.nlm.nih.gov/pubmed/17174996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2006.11.016
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