Glucuronidation of Monohydroxylated Warfarin Metabolites by Human Liver Microsomes and Human Recombinant UDP-Glucuronosyltransferases

Our understanding of human phase II metabolic pathways which facilitate detoxification and excretion of warfarin (Coumadin) is limited. The goal of this study was to test the hypothesis that there are specific human hepatic and extrahepatic UDP-glucuronosyltransferase (UGT) isozymes, which are respo...

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מידע ביבליוגרפי
Main Authors: Zielinska, Agnieszka, Lichti, Cheryl F., Bratton, Stacie, Mitchell, Neil C., Gallus-Zawada, Anna, Le, Vi-Huyen, Finel, Moshe, Miller, Grover P., Radominska-Pandya, Anna, Moran, Jeffery H.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2007
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275122/
https://ncbi.nlm.nih.gov/pubmed/17921187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.129858
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