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Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2
Mutations are introduced into rearranged Ig variable genes at a frequency of 10(−2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
1998
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC22699/ https://ncbi.nlm.nih.gov/pubmed/9618520 |
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