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Altered spectra of hypermutation in DNA repair-deficient mice.

Affinity maturation of the humoral immune response is based on the ability of immunoglobulin variable genes to undergo a process of rapid and extensive somatic mutation followed by antigenic selection for antibodies with higher affinity. While the behaviour of this somatic hypermutation phenomenon h...

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Dettagli Bibliografici
Autori principali: Winter, D B, Gearhart, P J
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087685/
https://ncbi.nlm.nih.gov/pubmed/11205330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0742
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