Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

Mutations are introduced into rearranged Ig variable genes at a frequency of 10(−2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair...

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Detalhes bibliográficos
Main Authors: Winter, David B., Phung, Quy H., Umar, Asad, Baker, Sean M., Tarone, Robert E., Tanaka, Kiyoji, Liskay, R. Michael, Kunkel, Thomas A., Bohr, Vilhelm A., Gearhart, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22699/
https://ncbi.nlm.nih.gov/pubmed/9618520
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