Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(−/−) animals develop intestinal tumors....
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22005/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359802/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6850 |
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