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Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(−/−) animals develop intestinal tumors....

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Autori principali: Yao, Xiang, Buermeyer, Andrew B., Narayanan, Latha, Tran, Doan, Baker, Sean M., Prolla, Tomas A., Glazer, Peter M., Liskay, R. Michael, Arnheim, Norman
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC22005/
https://ncbi.nlm.nih.gov/pubmed/10359802
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