Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(−/−) animals develop intestinal tumors....

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Hlavní autoři: Yao, Xiang, Buermeyer, Andrew B., Narayanan, Latha, Tran, Doan, Baker, Sean M., Prolla, Tomas A., Glazer, Peter M., Liskay, R. Michael, Arnheim, Norman
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22005/
https://ncbi.nlm.nih.gov/pubmed/10359802
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