Different mutator phenotypes in Mlh1- versus Pms2-deficient mice

Deficiencies in DNA mismatch repair (MMR) result in increased mutation rates and cancer risk in both humans and mice. Mouse strains homozygous for knockouts of either the Pms2 or Mlh1 MMR gene develop cancer but exhibit very different tumor spectra; only Mlh1(−/−) animals develop intestinal tumors....

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Detalhes bibliográficos
Main Authors: Yao, Xiang, Buermeyer, Andrew B., Narayanan, Latha, Tran, Doan, Baker, Sean M., Prolla, Tomas A., Glazer, Peter M., Liskay, R. Michael, Arnheim, Norman
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22005/
https://ncbi.nlm.nih.gov/pubmed/10359802
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