Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

The Pms2 gene has been implicated in hereditary colon cancer and is one of several mammalian homologs of the Escherichia coli mutL DNA mismatch repair gene. To determine the effect of Pms2 inactivation on genomic integrity in vivo, hybrid transgenic mice were constructed that carry targeted disrupti...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Narayanan, Latha, Fritzell, James A., Baker, Sean M., Liskay, R. Michael, Glazer, Peter M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20332/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096356/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3122
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