Assessing pathogenicity of <it>MLH1 </it>variants by co-expression of human <it>MLH1 </it>and <it>PMS2 </it>genes in yeast
<p>Abstract</p> <p>Background</p> <p>Loss of DNA mismatch repair (MMR) in humans, mainly due to mutations in the <it>hMLH1 </it>gene, is linked to hereditary nonpolyposis colorectal cancer (HNPCC). Because not all <it>MLH1 </it>alterations result in loss of MMR function, accurate characterization of...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BMC
2009-10-01
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| Series: | BMC Cancer |
| Acceso en liña: | http://www.biomedcentral.com/1471-2407/9/382 |
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