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Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

Mutations are introduced into rearranged Ig variable genes at a frequency of 10(−2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair...

詳細記述

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書誌詳細
主要な著者: Winter, David B., Phung, Quy H., Umar, Asad, Baker, Sean M., Tarone, Robert E., Tanaka, Kiyoji, Liskay, R. Michael, Kunkel, Thomas A., Bohr, Vilhelm A., Gearhart, Patricia J.
フォーマット: Artigo
言語:Inglês
出版事項: The National Academy of Sciences 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC22699/
https://ncbi.nlm.nih.gov/pubmed/9618520
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