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Structural Analysis of Actinorhodin Polyketide Ketoreductase: Cofactor Binding and Substrate Specificity

Aromatic polyketides are a class of natural products that include many pharmaceutically important aromatic compounds. Understanding the structure and function of PKS will provide clues to the molecular basis of polyketide biosynthesis specificity. Polyketide chain reduction by ketoreductase (KR) pro...

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Autors principals: Korman, Tyler Paz, Hill, Jason Anthony, Vu, Thanh Nhat, Tsai, Shiou-Chuan
Format: Artigo
Idioma:Inglês
Publicat: 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2263080/
https://ncbi.nlm.nih.gov/pubmed/15544323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi048133a
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