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The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase (ActKR)
In the actinorhodin type II polyketide synthase, the first polyketide modification is a regiospecific C9-carbonyl reduction, catalyzed by the ketoreductase (actKR). Our previous studies identified the actKR 94-PGG-96 motif as a determinant of stereospecificity (Javidpour, et al., 2011). The molecula...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855848/ https://ncbi.nlm.nih.gov/pubmed/24035284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.07.016 |
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