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Molecular Basis for Polyketide Ketoreductase–Substrate Interactions

Polyketides are a large class of structurally and functionally diverse natural products with important bioactivities. Many polyketides are synthesized by reducing type II polyketide synthases (PKSs), containing transiently interacting standalone enzymes. During synthesis, ketoreductase (KR) catalyze...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Zhao, Shiji, Ni, Fanglue, Qiu, Tianyin, Wolff, Jacob T., Tsai, Shiou-Chuan, Luo, Ray
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588967/
https://ncbi.nlm.nih.gov/pubmed/33066287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207562
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