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Crystal structure and functional analysis of tetracenomycin ARO/CYC: Implications for cyclization specificity of aromatic polyketides

Polyketides are a class of natural products with highly diverse chemical structures and pharmaceutical activities. Polyketide cyclization, promoted by the aromatase/cyclase (ARO/CYC), helps diversify aromatic polyketides. How the ARO/CYC promotes highly specific cyclization is not well understood be...

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Detalhes bibliográficos
Main Authors: Ames, Brian Douglas, Korman, Tyler Paz, Zhang, Wenjun, Smith, Peter, Vu, Thanh, Tang, Yi, Tsai, Shiou-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291100/
https://ncbi.nlm.nih.gov/pubmed/18388203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709223105
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