Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

Polyketides are a class of natural products with diverse structures and biological activities. The structural variability of aromatic products of fungal nonreducing, multidomain iterative polyketide synthases (NR-PKS group of IPKSs) results from regiospecific cyclizations of reactive poly-β-keto int...

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Main Authors: Crawford, Jason M., Korman, Tyler P., Labonte, Jason W., Vagstad, Anna L., Hill, Eric A., Kamari-Bidkorpeh, Oliver, Tsai, Shiou-Chuan, Townsend, Craig A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872118/
https://ncbi.nlm.nih.gov/pubmed/19847268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08475
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