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Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg

The His46Arg (H46R) mutant of human copper-zinc superoxide dismutase (SOD1) is associated with an unusual, slowly progressing form of familial amyotrophic lateral sclerosis (FALS). Here we describe in detail the crystal structures of pathogenic H46R SOD1 in the Zn-loaded (Zn-H46R) and metal-free (ap...

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Bibliografiske detaljer
Main Authors: Antonyuk, Svetlana, Elam, Jennifer Stine, Hough, Michael A., Strange, Richard W., Doucette, Peter A., Rodriguez, Jorge A., Hayward, Lawrence J., Valentine, Joan Selverstone, Hart, P. John, Hasnain, S. Samar
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253262/
https://ncbi.nlm.nih.gov/pubmed/15840828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041256705
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