Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis

Mutations in the gene encoding human copper-zinc superoxide dismutase (SOD1) cause a dominant form of the progressive neurodegenerative disease amyotrophic lateral sclerosis. Transgenic mice expressing the human G85R SOD1 variant develop paralytic symptoms concomitant with the appearance of SOD1-enr...

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Detalhes bibliográficos
Main Authors: Cao, Xiaohang, Antonyuk, Svetlana V., Seetharaman, Sai V., Whitson, Lisa J., Taylor, Alexander B., Holloway, Stephen P., Strange, Richard W., Doucette, Peter A., Valentine, Joan Selverstone, Tiwari, Ashutosh, Hayward, Lawrence J., Padua, Shelby, Cohlberg, Jeffrey A., Hasnain, S. Samar, Hart, P. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2414278/
https://ncbi.nlm.nih.gov/pubmed/18378676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801522200
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