Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg

The His46Arg (H46R) mutant of human copper-zinc superoxide dismutase (SOD1) is associated with an unusual, slowly progressing form of familial amyotrophic lateral sclerosis (FALS). Here we describe in detail the crystal structures of pathogenic H46R SOD1 in the Zn-loaded (Zn-H46R) and metal-free (ap...

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Detalhes bibliográficos
Main Authors: Antonyuk, Svetlana, Elam, Jennifer Stine, Hough, Michael A., Strange, Richard W., Doucette, Peter A., Rodriguez, Jorge A., Hayward, Lawrence J., Valentine, Joan Selverstone, Hart, P. John, Hasnain, S. Samar
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253262/
https://ncbi.nlm.nih.gov/pubmed/15840828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041256705
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