Ligand binding and aggregation of pathogenic SOD1

Mutations in the gene encoding Cu/Zn superoxide dismutase-1 cause amyotrophic lateral sclerosis. Superoxide dismutase-1 mutations decrease protein stability and promote aggregation. The mutant monomer is thought to be an intermediate in the pathway from the superoxide dismutase-1 dimer to aggregate....

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Bibliografiske detaljer
Main Authors:	Wright, Gareth S.A., Antonyuk, Svetlana V., Kershaw, Neil M., Strange, Richard W., Samar Hasnain, S
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Pub. Group 2013
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3644087/ https://ncbi.nlm.nih.gov/pubmed/23612299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2750
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Ligand binding and aggregation of pathogenic SOD1

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