Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases

Mislocalization, cleavage, and aggregation of the human protein TDP-43 is found in many neurodegenerative diseases. As is the case with many other proteins that are completely or partially structurally disordered, production of full-length recombinant TDP-43 in the quantities necessary for structura...

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Udgivet i:iScience
Main Authors: Wright, Gareth S.A., Watanabe, Tatiana F., Amporndanai, Kangsa, Plotkin, Steven S., Cashman, Neil R., Antonyuk, Svetlana V., Hasnain, S. Samar
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7262455/
https://ncbi.nlm.nih.gov/pubmed/32480125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101159
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