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Structural and Biophysical Properties of Metal-Free Pathogenic SOD1 Mutants A4V and G93A
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the destruction of motor neurons in the spinal cord and brain. A subset of ALS cases are linked to dominant mutations in copper-zinc superoxide dismutase (SOD1). The pathogenic SOD1 variants A4V an...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787720/ https://ncbi.nlm.nih.gov/pubmed/19800308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.09.020 |
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