Structural and Biophysical Properties of Metal-Free Pathogenic SOD1 Mutants A4V and G93A

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease characterized by the destruction of motor neurons in the spinal cord and brain. A subset of ALS cases are linked to dominant mutations in copper-zinc superoxide dismutase (SOD1). The pathogenic SOD1 variants A4V an...

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Main Authors: Galaleldeen, Ahmad, Strange, Richard, Whitson, Lisa J., Antonyuk, Svetlana, Narayana, Narendra, Taylor, Alexander B., Schuermann, Jonathan P., Holloway, Stephen P., Hasnain, S. Samar, Hart, P. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787720/
https://ncbi.nlm.nih.gov/pubmed/19800308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2009.09.020
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