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Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg
The His46Arg (H46R) mutant of human copper-zinc superoxide dismutase (SOD1) is associated with an unusual, slowly progressing form of familial amyotrophic lateral sclerosis (FALS). Here we describe in detail the crystal structures of pathogenic H46R SOD1 in the Zn-loaded (Zn-H46R) and metal-free (ap...
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| Главные авторы: | , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253262/ https://ncbi.nlm.nih.gov/pubmed/15840828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041256705 |
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