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Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor

The cell wall in Gram-negative bacteria is surrounded by an outer membrane comprised of charged lipopolysaccharide (LPS) molecules that prevent entry of hydrophobic agents into the cell and protect the bacterium from many antibiotics. The hydrophobic anchor of LPS is lipid A, the biosynthesis of whi...

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Autores principales: Mochalkin, Igor, Knafels, John D., Lightle, Sandra
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2248309/
https://ncbi.nlm.nih.gov/pubmed/18287278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073324108
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