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Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor
The cell wall in Gram-negative bacteria is surrounded by an outer membrane comprised of charged lipopolysaccharide (LPS) molecules that prevent entry of hydrophobic agents into the cell and protect the bacterium from many antibiotics. The hydrophobic anchor of LPS is lipid A, the biosynthesis of whi...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2248309/ https://ncbi.nlm.nih.gov/pubmed/18287278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073324108 |
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