E47 is required for V(D)J recombinase activity in common lymphoid progenitors

Common lymphoid progenitors (CLPs) are the first bone marrow precursors in which V(D)J recombinase activity is up-regulated. Here, we show that loss of the transcription factor E47 produces a reduced CLP population that lacks V(D)J recombinase activity and D-J(H) rearrangements in vivo. Apart from a...

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Bibliografiske detaljer
Main Authors: Borghesi, Lisa, Aites, Jennifer, Nelson, Shakira, Lefterov, Preslav, James, Pamela, Gerstein, Rachel
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212960/
https://ncbi.nlm.nih.gov/pubmed/16365147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051190
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