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E47 is required for V(D)J recombinase activity in common lymphoid progenitors
Common lymphoid progenitors (CLPs) are the first bone marrow precursors in which V(D)J recombinase activity is up-regulated. Here, we show that loss of the transcription factor E47 produces a reduced CLP population that lacks V(D)J recombinase activity and D-J(H) rearrangements in vivo. Apart from a...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2212960/ https://ncbi.nlm.nih.gov/pubmed/16365147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20051190 |
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