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Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced
To understand the relationship between the affinity of the B cell antigen receptor (BCR) and the immune response to antigen, two lines of immunoglobulin H chain transgenic (Tg) mice were created. H50Gμ(a) and T1(V23)μ(a) mice express μ H chain transgenes that associate with the λ1 L chains to bind t...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193705/ https://ncbi.nlm.nih.gov/pubmed/11994427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011550 |
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