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What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination?: Breaking through Immunity’s Glass Ceiling

A key goal of HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bnAbs) targeted to the vulnerable regions of the HIV envelope. BnAbs develop over time in ∼50% of HIV-1-infected individuals. However, to date, no vaccines have induced bnAbs and few or none of these vaccine...

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書目詳細資料
發表在:Cold Spring Harb Perspect Biol
Main Authors: Kelsoe, Garnett, Haynes, Barton F.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736460/
https://ncbi.nlm.nih.gov/pubmed/28630077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a029397
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