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What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination?: Breaking through Immunity’s Glass Ceiling
A key goal of HIV-1 vaccine development is the induction of broadly neutralizing antibodies (bnAbs) targeted to the vulnerable regions of the HIV envelope. BnAbs develop over time in ∼50% of HIV-1-infected individuals. However, to date, no vaccines have induced bnAbs and few or none of these vaccine...
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| Izdano u: | Cold Spring Harb Perspect Biol |
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| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cold Spring Harbor Laboratory Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5736460/ https://ncbi.nlm.nih.gov/pubmed/28630077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a029397 |
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