What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination?: Is Affinity Maturation a Self-Defeating Process for Eliciting Broad Protection?

Vaccinations are one of the greatest success stories of modern medicine, saving millions of lives since their widespread adoption. However, several diseases continue to elude highly effective vaccination strategies. Chief among these are human immunodeficiency virus (HIV) and influenza (flu), both o...

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Bibliographic Details
Published in:Cold Spring Harb Perspect Biol
Main Authors: Stamper, Christopher T., Wilson, Patrick C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2018
Subjects:
Perspectives
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899041/
https://ncbi.nlm.nih.gov/pubmed/28630076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a028803
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