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Role of germinal centers for the induction of broadly-reactive memory B cells

Virus-specific memory B cells (B(mem)) play a crucial role in protecting against variant viruses. The ability to recognize these variant viruses, defined as antibody breadth, is achieved in B(mem) populations by two very different pathways, germline-encoded cross-reactivity and affinity-driven, soma...

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Detalhes bibliográficos
Publicado no:Curr Opin Immunol
Main Authors: Takahashi, Yoshimasa, Kelsoe, Garnett
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449227/
https://ncbi.nlm.nih.gov/pubmed/28355576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2017.03.002
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