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Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC), perhaps by increased acquisition of antigen for presentation to follicular helper T cells and improved T-cell help. In this model for affinity-dependent selection, the density of peptide/MHCII (pMHCII) comple...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yeh, Chen-Hao, Nojima, Takuya, Kuraoka, Masayuki, Kelsoe, Garnett
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834622/
https://ncbi.nlm.nih.gov/pubmed/29500348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03382-x
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