Complex Antigens Elicit Diverse Patterns of Clonal Selection in Germinal Centers

Germinal center (GC) B cells evolve towards increased affinity by a Darwinian process that has been studied primarily in genetically restricted, hapten-specific responses. We explored the population dynamics of genetically diverse GC responses to two complex antigens – Bacillus anthracis protective...

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Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Kuraoka, Masayuki, Schmidt, Aaron G., Nojima, Takuya, Feng, Feng, Watanabe, Akiko, Kitamura, Daisuke, Harrison, Stephen C., Kepler, Thomas B., Kelsoe, Garnett
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794380/
https://ncbi.nlm.nih.gov/pubmed/26948373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.02.010
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