NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP

Fas (APO-1/CD95) is the prototypic death receptor, and the molecular mechanisms of Fas-induced apoptosis are comparably well understood. Here, we show that Fas activates NFκB via a pathway involving RIP, FADD, and caspase-8. Remarkably, the enzymatic activity of the latter was dispensable for Fas-in...

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Main Authors: Kreuz, Sebastian, Siegmund, Daniela, Rumpf, Jost-Julian, Samel, Dierk, Leverkus, Martin, Janssen, Ottmar, Häcker, Georg, Dittrich-Breiholz, Oliver, Kracht, Michael, Scheurich, Peter, Wajant, Harald
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2004
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172264/
https://ncbi.nlm.nih.gov/pubmed/15289496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200401036
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