Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

Interferons (IFNs) are cytokines with powerful immunomodulatory and antiviral properties, but less is known about how they induce cell death. Here, we show that both type I (α/β) and type II (γ) IFNs induce precipitous receptor-interacting protein (RIP)1/RIP3 kinase-mediated necrosis when the adapto...

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Autores principales: Thapa, Roshan J., Nogusa, Shoko, Chen, Peirong, Maki, Jenny L., Lerro, Anthony, Andrake, Mark, Rall, Glenn F., Degterev, Alexei, Balachandran, Siddharth
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746924/
https://ncbi.nlm.nih.gov/pubmed/23898178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301218110
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