NF-κB Protects Cells from Gamma Interferon-Induced RIP1-Dependent Necroptosis

Interferons (IFNs) are cytokines with well-described immunomodulatory and antiviral properties, but less is known about the mechanisms by which they promote cell survival or cell death. Here, we show that IFN-γ induces RIP1 kinase-dependent necroptosis in mammalian cells deficient in NF-κB signaling...

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Detalhes bibliográficos
Main Authors: Thapa, Roshan J., Basagoudanavar, Suresh H., Nogusa, Shoko, Irrinki, Krishna, Mallilankaraman, Karthik, Slifker, Michael J., Beg, Amer A., Madesh, Muniswamy, Balachandran, Siddharth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3133390/
https://ncbi.nlm.nih.gov/pubmed/21576359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05445-11
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