cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the spontaneous formation of an intracellular platform that activates either apoptosis or necroptosis. This 2 MDa intracellular complex that we designate “Ripoptosome” is necessa...

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Main Authors: Feoktistova, Maria, Geserick, Peter, Kellert, Beate, Dimitrova, Diana Panayotova, Langlais, Claudia, Hupe, Mike, Cain, Kelvin, MacFarlane, Marion, Häcker, Georg, Leverkus, Martin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Press 2011
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163271/
https://ncbi.nlm.nih.gov/pubmed/21737330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.011
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