cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation

Cellular inhibitor of apoptosis proteins (cIAPs) have emerged as important anti-cell death mediators, particularly in cancer. Although they are known to be expressed in immune tissue, their specific immune function remains unclear. We observed that degradation of cIAPs with SMAC mimetic (SM) results...

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Detalhes bibliográficos
Main Authors: McComb, S, Cheung, H H, Korneluk, R G, Wang, S, Krishnan, L, Sad, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469059/
https://ncbi.nlm.nih.gov/pubmed/22576661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.59
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