cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

The intracellular regulation of cell death pathways by cIAPs has been enigmatic. Here we show that loss of cIAPs promotes the spontaneous formation of an intracellular platform that activates either apoptosis or necroptosis. This 2 MDa intracellular complex that we designate “Ripoptosome” is necessa...

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Bibliografiske detaljer
Main Authors: Feoktistova, Maria, Geserick, Peter, Kellert, Beate, Dimitrova, Diana Panayotova, Langlais, Claudia, Hupe, Mike, Cain, Kelvin, MacFarlane, Marion, Häcker, Georg, Leverkus, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3163271/
https://ncbi.nlm.nih.gov/pubmed/21737330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.06.011
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