TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP

cFLIP is required for epidermal integrity and skin inflammation silencing via protection from TNF-induced keratinocyte apoptosis. Here, we generated and analyzed cFLIP epidermal KO mice with additional TNF deficiency. Intriguingly, the ablation of TNF rescued the pathological phenotype of epidermal...

Full description

Saved in:
Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Feoktistova, Maria, Makarov, Roman, Leverkus, Martin, Yazdi, Amir S., Panayotova-Dimitrova, Diana
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700656/
https://ncbi.nlm.nih.gov/pubmed/33238518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228859
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items