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NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

The caspase 8 homologue FLICE-inhibitory protein (cFLIP) is a potent negative regulator of death receptor-induced apoptosis. We found that cFLIP can be upregulated in some cell lines under critical involvement of the NF-κB pathway, but NF-κB activation was clearly not sufficient for cFLIP induction...

詳細記述

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書誌詳細
主要な著者: Kreuz, Sebastian, Siegmund, Daniela, Scheurich, Peter, Wajant, Harald
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC87059/
https://ncbi.nlm.nih.gov/pubmed/11359904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.12.3964-3973.2001
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