Distinct Activation Mechanisms of NF-κB Regulator Inhibitor of NF-κB Kinase (IKK) by Isoforms of the Cell Death Regulator Cellular FLICE-like Inhibitory Protein (cFLIP)

The viral FLICE-like inhibitory protein (FLIP) protein from Kaposi sarcoma-associated herpesvirus activates the NF-κB pathway by forming a stable complex with a central region (amino acids 150–272) of the inhibitor of NF-κB kinase (IKK) γ subunits, thereby activating IKK. Cellular FLIP (cFLIP) forms...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Baratchian, Mehdi, Davis, Christopher A., Shimizu, Akira, Escors, David, Bagnéris, Claire, Barrett, Tracey, Collins, Mary K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817188/
https://ncbi.nlm.nih.gov/pubmed/26865630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718122
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