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NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
Fas (APO-1/CD95) is the prototypic death receptor, and the molecular mechanisms of Fas-induced apoptosis are comparably well understood. Here, we show that Fas activates NFκB via a pathway involving RIP, FADD, and caspase-8. Remarkably, the enzymatic activity of the latter was dispensable for Fas-in...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2004
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172264/ https://ncbi.nlm.nih.gov/pubmed/15289496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200401036 |
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