Regulation of mTOR and S6K1 Activation by the nPKC isoforms, PKC(ε) and PKC(δ), in Adult Cardiac Muscle Cells

Activation of both mTOR and its downstream target, S6K1 (p70 S6 kinase) have been implicated to affect cardiac hypertrophy. Our earlier work, in a feline model of 1–48 h pressure overload, demonstrated that mTOR/S6K1 activation occurred primarily through a PKC/c-Raf pathway. To further delineate the...

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Bibliografiska uppgifter
Huvudupphovsmän: Moschella, Phillip C., Rao, Vijay U., McDermott, Paul J., Kuppuswamy, Dhandapani
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2170873/
https://ncbi.nlm.nih.gov/pubmed/17976640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2007.09.015
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