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Regulation of mTOR and S6K1 Activation by the nPKC isoforms, PKC(ε) and PKC(δ), in Adult Cardiac Muscle Cells
Activation of both mTOR and its downstream target, S6K1 (p70 S6 kinase) have been implicated to affect cardiac hypertrophy. Our earlier work, in a feline model of 1–48 h pressure overload, demonstrated that mTOR/S6K1 activation occurred primarily through a PKC/c-Raf pathway. To further delineate the...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2170873/ https://ncbi.nlm.nih.gov/pubmed/17976640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2007.09.015 |
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