Conflicting Requirements of Plasmodium falciparum Dihydrofolate Reductase Mutations Conferring Resistance to Pyrimethamine-WR99210 Combination

Plasmodium falciparum strains bearing quadruple mutations of dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) at codons 51, 59, 108, and 164 are highly resistant to pyrimethamine (PYR), a diaminopyrimidine, but sensitive to WR99210 (WR), a cycloguanil analog, suggesting different enzyme-inhi...

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Detaylı Bibliyografya
Asıl Yazarlar: Japrung, Deanpen, Leartsakulpanich, Ubolsree, Chusacultanachai, Sudsanguan, Yuthavong, Yongyuth
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology (ASM) 2007
Konular:
Mechanisms of Resistance
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167985/
https://ncbi.nlm.nih.gov/pubmed/17875995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00577-07
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