Conflicting Requirements of Plasmodium falciparum Dihydrofolate Reductase Mutations Conferring Resistance to Pyrimethamine-WR99210 Combination

Plasmodium falciparum strains bearing quadruple mutations of dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) at codons 51, 59, 108, and 164 are highly resistant to pyrimethamine (PYR), a diaminopyrimidine, but sensitive to WR99210 (WR), a cycloguanil analog, suggesting different enzyme-inhi...

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Main Authors: Japrung, Deanpen, Leartsakulpanich, Ubolsree, Chusacultanachai, Sudsanguan, Yuthavong, Yongyuth
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2007
Ábhair:
Mechanisms of Resistance
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2167985/
https://ncbi.nlm.nih.gov/pubmed/17875995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00577-07
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